AAHSD004607
Additional Field Safety Testing of Canine Osteosarcoma Vaccine, Live Listeria Vector


Investigator:
Lydia Cook McAnulty

Species:
Canine

Primary Location: ?
Las Vegas Veterinary Specialty Center -- Las Vegas, Nevada

Recruitment Status:
Recruiting

Interested in
Participating
in the study?


Primary Study Contact:
Elizabeth Jackson
customerservice@aratana.com
1-844-272-8262


Recruitment Start Date:
02/15/2018

Recruitment End Date:
02/15/2019

Results Posted:


Funding Source:
Company

 

Animal owners interested in participating in a study are encouraged to discuss their eligibility for any relevant study with their veterinarian.
  • Project Description
    • This study is designed to collect additional safety data for Canine Osteosarcoma Vaccine, Live Listeria Vector (AT-014), which is conditionally licensed by the United States Department of Agriculture (USDA). Dogs must have undergone amputation of the affected limb and have completed chemotherapy prior to entering the study. 

      Not all sites are currently enrolling patients. Please contact sites directly to determine eligibility and timing of possible enrollment.

  • Secondary Location(s)
    • Southern Arizona Veterinary Specialty and Emergency Center
      Tucson, Arizona

      Veterinary Cancer Group of Los Angeles
      Culver City, California

      SAGE Centers for Veterinary Specialty and Emergency Care
      Campbell, California

      Veterinary Specialty Hospital by ETHOS
      San Diego, California

      VRCC Veterinary Specialty & Emergency Hospital
      Englewood, Colorado

      Veterinary Cancer Center
      Norwalk, Connecticut

      Southeast Veterinary Oncology and Internal Medicine
      Jacksonville, Florida

      Blue Pearl Specialty + Emergency Pet Hospital - Tampa, FL
      Tampa, Florida

      MedVet Medical & Cancer Centers for Pets - Indiana
      Carmel, Indiana

      Iowa State University
      Ames, Iowa

      Blue Pearl Specialty + Emergency Pet Hospital - Overland Park
      Overland Park, Kansas

      New England Veterinary Oncology Group
      Waltham, Massachusetts

      Blue Pearl Specialty + Emergency Pet Hospital
      Southfield, Michigan

      Oradell Animal Hospital
      Paramus, New Jersey

      VCA Veterinary Care Animal Hospital and Referral Center
      Albuquerque, New Mexico

      Katonah Bedford Veterinary Center
      Bedford Hills, New York

      MedVet Medical & Cancer Centers for Pets - Columbus
      Worthington, Ohio

      Veterinary Cancer & Surgery Specialists
      Milwaukie, Oregon

      Hope Veterinary Specialists
      Malvern, Pennsylvania

      Upstate Veterinary Specialists
      Greenville, South Carolina

      Sugar Land Veterinary Specialists and Emergency Care
      Sugar Land, Texas

      Veterinary Specialist of North Texas
      Ft. Worth, Texas

      The LifeCentre
      Springfield, Virginia

      Bridge Animal Referral Center
      Edmonds, Washington

      Wisconsin Veterinary Referral Center
      Waukesha, Wisconsin
  • Study Type
    • Interventional
  • Intervention
    • biologic/ vaccine
  • Inclusion Criteria
    • 1. Signed Owner Informed Consent 

      2. Client owned dog > 1 year of age

      3. Body weight ≥ 2 kg

      4. Histopathologic or cytologic diagnosis of osteosarcoma

      5. Amputation of the affected limb followed by a completed chemotherapy regimen

      6. ECOG Performance score of 0 or 1 [0=normal activity; 1=restricted activity, decreasedactivity from pre‐disease status, 2= compromised, ambulatory only for vital activities,consistently defecates and urinates in acceptable areas]

  • Exclusion Criteria
    • 1. Clinically relevant abnormalities on CBC/CS/UA

      2. Evidence of pulmonary metastases on 3‐view thoracic radiographs

      3. Prior immunotherapeutic treatment for osteosarcoma

      4. Any uncontrolled medical condition (including other concurrent malignancy) that may be disruptive to the intent and objectives of the study

      5. Dog is pregnant, lactating or likely to become pregnant

      6. Dog is participating in another study

      7. Dog may not be available for the entire study duration

  • Potential Medical Benefits to Enrolled Animals
    • Potential medical benefits should be discussed with the Investigator
  • Potential Medical Risks to Enrolled Animals
    • Potential medical risks should be discussed with the Investigator
  • Financial Incentives for Study Participants
    • Not Specified
  • Study Results